At a Glance
The Red Devils' poor recent struggles continued at Leeds' fortress, but head coach Ruben Amorim had Matheus Cunha to thank for the team avoiding even more damage against their old rivals.
The Everton loanee headed a first-half effort against the woodwork for the in-form hosts before Brenden Aaronson finished superbly with a driven, 62nd-minute effort.
At that stage, the United boss was under intense scrutiny after his side had failed to beat struggling Wolverhampton Wanderers at home earlier in the week.
However, against a team who had two days less to prepare, the forward levelled three minutes after the opener when he ran on to a pass from introduced the Dutchman and guided a shot underneath advancing home goalkeeper Lucas Perri.
It was only the South American's fourth Premier League goal since his big-money summer move and came at a time when the manager is without four key attacking players due to a combination of injury and national team commitments.
Not that you would expect Leeds to sympathise with that given their own tight schedule.
The Swiss attacker forced a full length save out of Manchester United goalkeeper Senne Lammens with a audacious overhead kick, and visiting heads were in hands when the Slovenian striker, who is finding it hard to make an impression, turned Zirkzee's cut-back wide from close range.
The goalscorer, who had a goal ruled out for offside much earlier in the contest, also fired against a post late on.
The draw extends the home side's unbeaten run to seven matches, their longest such streak since over two decades ago, and takes them a significant margin clear of the drop zone.
For the Manchester United though, it was yet another opportunity to move into the Champions League places, albeit only for a short time, wasted.
With the Africa Cup of Nations reaching its knockout phase, the United coach could be understood for hoping the involved countries make a swift exit.
Current injuries to skipper Bruno Fernandes and Three Lions star Mason Mount only exacerbated the impact the unavailability of other attackers is having on the team's options.
It's not that the absent players are the solution to all of United's problems. After all, they were part of the side that suffered disappointing results earlier in the campaign.
But without them, the boss has few alternatives in attack.
He evidently does not trust youngster Shea Lacey or the much more experienced Zirkzee, even though the Dutch forward provided the assist for Cunha's equaliser almost immediately after his introduction as a replacement.
That leaves the Brazilian, who has now scored a small tally in five games, and others operating out of their preferred positions, alongside Sesko.
On this evidence, the big-money frontman looks no better than previous underwhelming signings, lacking in confidence and assurance in front of goal.
His failure to turn home Zirkzee's cross means it is now nine games without a goal for the new signing.
After thrilling victories in their last few home games, the arrival of their fiercest rivals to Elland Road was a comparatively subdued affair.
True, there were moments of expected fervor, but the hostile edge was not as evident as in other fixtures.
The home fans were more preoccupied about their side's inability to get sustained possession in dangerous areas for any prolonged period.
The striker's header that clipped the post was an isolated moment of quality in a congested first half.
It still felt as though the hosts were finding it tough when a mistake opened the door for the opener.
Ever so briefly, Leeds' delirious fans thought they were about to secure a coveted win against Manchester United.
However, there is a wider context for Daniel Farke and the club to deal with.
When they suffered a poor run of form earlier in the season, many speculated about the manager's position.
Instead, he is now masterminding clear improvement.
The job is not done yet but gradually, Leeds are getting nearer to securing their top-flight status.
Leeds have a Premier League trip to St James' Park in midweek, followed by the start of their domestic cup campaign next weekend. Manchester United face a Premier League trip to Burnley before also beginning their FA Cup journey with a home tie.